Stan Bleszynski's heretical ideas on science, optimal human nutrition etc.
@stanble
2008 - Age of Awakening / 2016 - Age of disclosures / 2021 - Age of Making Choices & Separation / Next Stage - Age of Reconnection and Transition! / 2024 - Two millenia-old Rational Collectivist societal cycle gives way to the Self-Empowered Individualism. / 2025 Golden Age begins
"HF LC diet" = High Fat Low Carbohydrate diet (dr. Jan Kwasniewski's "Optimal Diet")
Quotes:
Introduction. So called “optimal diet” – a low-carbohydrate, high-fat
diet, different from Atkins diet – has become very popular in Poland
during the last 20 years. It is very controversial; official dietetics in
Poland claim it is extremely noxious.
Aim [Objectives]. To check what are the effects of so-called “optimal diet” on
health status, frame of mind of people, their physical activity and
diseases including type 2 diabetes.
Material and methods. 436 persons aged 20-75 years, both
women (247) and men (189) were examined. 231 of them applied
“optimal diet” and 205 did not. 86 confirmed they suffered from
type 2 diabetes. All examined persons were inquired with our own
questionnaire.
Results. Quite a lot of statistically significant dependencies were
found to exist. They show us that persons applying the “optimal
diet” might be physically active longer than the persons not applying
it. The majority of the “optimal diet” users claim they got rid of
overweight owing to this diet. Quite many of them claim they
cured themselves of the diabetes or at least the diabetes distress
has distinctly diminished.
Conclusions.The persons applying the “optimal diet” claim they
got rid of overweight or even cured themselves of the diabetes
owing to the diet. Our data do seem to confirm the last reports
(Al-Khalifa et al. 2009).
Fig.1 and Fig.2
Explanations to Fig.1:
"stosujący DO" = Using Optimal Diet,
"nie stosujący OD" = Not using Optimal Diet.
Horizontal axis:
Answers to the question: “Are you suffering from diabetes at present?”
"Tak" = Yes,
"Nie, ale kiedyś chorowałem/łam" = No but I used to suffer from it.
Explanations to Fig.2:
"stan cukrzycy nie zmienił się" = diabetes status hasn't changed
"cukrzyca zaczęła spadać" = diabetes started to recede
"Over half of the respondents were able (in their opinion)
to heal themselves of diabetes using the so-called optimal diet [OD], but it was not possible for anyone (according to respondents' opinions) who did not follow the OD."
Long-term, high nut consumption could be the key to better cognitive health in older people according to new research from the University of South Australia.
In a study of 4822 Chinese adults aged 55+ years, researchers found that eating more than 10 grams of nuts a day was positively associated with better mental functioning, including improved thinking, reasoning and memory.
Lead researcher, UniSA’s Dr Ming Li, says the study is the first to report an association between cognition and nut intake in older Chinese adults, providing important insights into increasing mental health issues (including dementia) faced by an ageing population.
“Population aging is one of the most substantial challenges of the twenty-first century. Not only are people living longer, but as they age, they require additional health support which is placing unprecedented pressure on aged-care and health services,” Dr Li says.
It has been noticed that ketone bodies producing diets such as calorie-restricted diet and ketogenic diets exert some anti-aging effects (on test animals). This study, see the article linked below, pinpoints the mechanism of this effect to the specific ketone body molecule: β-Hydroxybutyrate.
In their study, the research team explores the link between calorie restriction (eating less or fasting) and delaying aging, which is unknown and has been poorly studied. The findings are published in the journal Molecular Cell.
The researchers identified an important, small molecule that is produced during fasting or calorie restriction conditions. The molecule, β-Hydroxybutyrate, is one type of a ketone body, or a water-soluble molecule that contains a ketone group and is produced by the liver from fatty acids during periods of low food intake, carbohydrate restrictive diets, starvation and prolonged intense exercise.
The researchers reported that β-Hydroxybutyrate delays vascular aging by providing a chemical link between calorie restriction and fasting and the anti-aging effect.
This compound can delay vascular aging of the endothelial cells, which line the interior surface of blood vessels and lymphatic vessels, preventing a type of cell aging called senescence, or cellular aging.
Senescent cells can no longer multiple and divide. The researchers found β-Hydroxybutyrate can promote cell division and prevent these cells from becoming old. Because this molecule is produced during calorie restriction or fasting, when people overeat or become obese this molecule is possibly suppressed, which would accelerate aging.
In addition, the researchers found when β-Hydroxybutyrate binds to a certain RNA-binding protein, this increases activity of a stem cell factor called Octamer-binding transcriptional factor (Oct4) in vascular smooth muscle and endothelial cells in mice.
Stem cell factor Oct4 increases a key factor against DNA damage-induced senescence, which can keep blood vessels young.
Reference:
1. "β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4",
Young-min Han et al., Molecular Cell, VOLUME 71, ISSUE 6, P1064-1078.E5, SEPTEMBER 20, 2018.
Example of a ketogenic (high fat low carb) dish. Ketogenic diet has been described by some as BBB diet, meaning Butter, Bacon and Brie. It is not limited to that!
I highly recommend to listen to her video. She is reviewing some old studies showing therapeutic effects of the very low fat high carbohydrate diets (VLFHC). Low fat means well below 10% preferably about 2%. When I begun my high fat low carb experiment back in 1999, which grew into my ongoing lifestyle nutrition to this day, I was aware that the very low fat natural food diet has been successfully used in halting progression of coronary heart disease and MS. I was familiar about Pritikin and Dr. Swank work. Prior to 1999 I was experimenting with vegetarian nutrition but I found it unpalatable, unless a sufficient amount of fat was added. More than 10%. So for me finding dr. Kwasniewski's Optimal Diet was a "gift from God", or I should say a gift from a friend of mine (Andrew S.)! Kwasniewski's Optimal Diet is high animal fat low carb diet (HFLC). After noticing back then that the VLFHC diets have some therapeutic property, I had many questions (i.e. "question everything"). One of them is about the long term viability and the side effects. Like with every therapy, there may be side effects. Are there side effects of VLFHC diets? How do people do on such nutrition scheme fare in the long term? Longevity issue? Longevity with a robust health or not so well? The same question can also be asked about any other diet, including the HFLC diet.
Unlike most other low carb promoters at that time (1970-ties - 1990-ties), dr. Kwasniewski did acknowledge that a high carbohydrate diet may also be healthy, quoting Japanese rice based diet as an example. He also insisted that, on such a diet (1) fat intake must be limited to abut 10% and (2) a sufficient amount of (lean) protein must be consumed. Insulin sensitivity is very high on such a diet because the intake of fat is very low but the pancreatic insulin secretion is medium. Insulin cannot be too low, due to carbohydrate-based metabolism. Typically it amounts to about 20-30 iu per day, based on my understanding and from reports by t1 diabetics (quoting from memory so verify this before you requote me!)
Dr. Kwasniewski also noticed, based on his patients record, that a particular proportion of macronutrients, consisting of about 35-45% of fat (by calories) and about 45-35% of carbohydrates is particulary unhealthy and makes people prone to developing diabetes and atherosclerotic heart disease. Kwasniewski also noticed that it causes a peculiar form of neuro-degeneration for people in their 40-ties and 50-ties manifesting itself in form character disorder (psychopathy). He called that dietary zone "dangerous middle zone". Pancreatic insulin secretion has to be very high (typically 40-60 iu/day or more) on such a diet in order to overcome the insulin insensitivity induced by the high fat intake.
He also noticed that as soon as you up the total fat intake to above 50% of calories then these pathological effects gradually subside and the diet becomes healthy again, even therapeutically healthy. The widely popular diet he publicized in the 1980-ties, arrived at the macronutrient proportions P:F:C (Protein to Fat to Carbohydrates) in gram per day per 1kg of ideal body weight of 1:3-3.5:0.8 to 1:2-2.5:0.5 . This typically works out at way over 60% (typ about 85%) of fat by calories. Notice that fat has 9kcal/g, glucose 4.5kcal/g and protein 3.5kcal/g (or less if used anabolically). Interestingly, Kwasniewski also found that his patients with coronary heart disease begun reversing and recovering. So his patients with many autoimmune disease such as asthma, rheumatoid arthritis, MS, IBS, and other - also recovered on his diet! Even though the HFLC diet is the exact opposite of the VLFHC diet, it nevertheless produced surprisingly similar (if not greater) therapeutic effects! Notice that the insulin sensitivity (and the effect of fat upon it) becomes irrelevant due to very low intake of carbohydrates. Kwasniewski quoted insulin requirement at this point, to be about 6-10 iu/day. How did he measured it? By observing his type 1 diabetic patients!
What Denise Minger has done, is rediscovering and publicizing that fact that there are 2 dietary zones that have therapeutic properties, not just one diet!
What I would disagree with, is her presumption that the VLFHC diet would:
- "results in healthier gut microbiome long term"
There is not proof or comparison studies done for VLFHC vs HFLC on that, while there is enough reports indicating the long term gut flora deterioration among vegans (I would put refs to Dr. Stanley Bass and Dr. Gian-Cursio reports on Natural Hygienists).
- "may do best for ApoE4 carriers"
No proof either, other than high serum cholesterol which does not always translate to a health risk, except for people eating in the dangerous middle zone.
- "may be able to restore and heal glucose tolerance which does not happen on the high fat..."
This is not true based on my personal observation. Initially yes, HFLC diet did not restore my glucose tolerance, it only allowed my body to bypass the issue by not showering my body with the excess carbohydrates. Whenever I tried to eat a little bit more than 50g of carbohydrates in a day, I would inevitably come to regret it! Carb-headache and nausea. Beer was especially bad for me. However, after about 2 years I noticed that I was able to increase that limit and add more than previously and after about 6-7 years I noticed that my carbohydrates tolerance has been totally restored! For example I can now consume a high carb dinner if I have no other choice without any adverse side effects. I don't do it often, but it is nice to know that my metabolism has completely been restored. I suspect it has to do with the mitochondrial regeneration. It takes about 7 years to regrow and renew most of our muscular tissues from our stem cells. I also found it that initially I had to watch not only the total carbohydrates intake, but I also had to limit the overall caloric intake from fat as well. Initially the total limit was about 1800kcal. Believe it or not that is actually perfectly sufficient for an adult leading an active life on the high fat diet, without any problems (I was 43 in 1999 when I begun HFLC and I weigh 64k, 173cm height) It was as if my metabolic channels were impaired for both macronutrients, for carbs as well as for fat, except the metabolism of fat, being more effective, allowed me to live better and have more energy in spite of the limitations. Again, that restriction is no longer applicable and lifted itself after about 7 years.
An 82 year old woman with chronic paranoid schizophrenia since age 17
The first patient documented in the Schizophrenia Research article is a woman who spent nearly her whole life suffering chronic, treatment-resistant schizophrenia. For more than 50 years, she endured paranoia, disorganized speech, visual and auditory hallucinations. By the time she was 70, she was suicidal and had been hospitalized repeatedly for psychosis or suicide attempts. She had been treated with over ten different antipsychotic and mood stabilizing medications, including regular antipsychotic injections. None of them helped her symptoms. She was unable to care for herself and had a court-appointed guardian and home health services.
At the age of 70, weighing 330 pounds, she went to a medical weight loss clinic and was started on a ketogenic diet. Within two weeks of starting the diet, she reported a noticeable reduction not only in her weight but also her psychotic symptoms. Within several months, she started to feel so much better that she was able to stop taking her psychiatric medications while remaining on the diet. Over time, her mood stabilized, and her hallucinations and paranoia remitted completely. She was no longer suicidal. Her case was first reported in 2009.
Today, 12 years later, she has lost a total of 150 pounds and remains on the ketogenic diet. She takes no medications and remains symptom-free. She was able to regain her independence, no longer requiring the guardian and the home health care team. When I recently spoke with her, she recalled her decades of suffering and hopelessness, and said that since starting the diet, she has had a "new life," and is happy to be alive.
A 39 year old woman with schizophrenia for 20 years
The second patient described in the article is a thirty-nine year old woman who suffered from depression, anxiety, anorexia nervosa, hallucinations and paranoia since her teens. As patients sometimes do, she concealed her psychotic symptoms when she was initially treated for depression and anorexia. When she finally reported her psychotic symptoms later in her twenties, she was diagnosed with schizophrenia. For the next ten years, she was treated with 7 different antipsychotic medications—including clozapine (called the “gold standard antipsychotic medication”) - along with antidepressants and anti-anxiety medications. Nevertheless, she continued to have symptoms.
She was having chronic gastrointestinal problems, so she saw a doctor who recommended the ketogenic diet. Noticing some improvement of her symptoms and being frustrated with all of her psychiatric medications, she unwisely stopped taking all 14 of her medications “cold turkey.” This sent her into severe psychosis requiring an extended hospitalization. In the hospital, she was re-medicated with Haldol-decanoate (an injectable medication which had not worked for her previously) and she continued the ketogenic diet. Within a month on both Haldol and the ketogenic diet, she reported complete remission of her psychotic symptoms for the first time since she was 14. Over the following year, she slowly tapered off Haldol, and remained free of psychotic symptoms. Of note, she lost 70 pounds from the diet, which exacerbated her anorexia. She has since regained 30 of those pounds and maintains a healthy weight today. 5 years after starting the ketogenic diet, she is off all antipsychotic medications, remains on the diet, and is free of all psychotic symptoms. She has since finished graduate school and now works full time.
Interestingly, these aren’t the first reports of the ketogenic diet for schizophrenia
While inspiring, these two case reports join a growing body of evidence supporting the use of the ketogenic diet in the treatment of schizophrenia.
Schizophrenia in 1965
In 1965, ten women hospitalized with schizophrenia who were already receiving medications and electroconvulsive therapy (ECT or “shock therapy”) were also placed on the ketogenic diet for a month. The researchers reported that their symptoms improved after two weeks on the diet, but then returned back to their baseline level of symptoms after the diet was stopped.
Schizoaffective disorder in 2017
In 2017, I reported two other cases of schizoaffective disorder improving significantly on the ketogenic diet. Schizoaffective disorder is a diagnosis that includes both a mix of schizophrenia and a mood disorder, often bipolar disorder. One man and one woman, both in their 30’s, had suffered treatment-resistant schizoaffective disorder for years. On the diet, their symptoms were greatly improved, and they both lost significant amounts of weight. Off the diet, their symptoms returned.
Schizophrenia in Ecuador
In 2018, two Ecuadorian twins, one male and one female, diagnosed with schizophrenia since the ages of 14 and 18 were started on a 6-week trial of the ketogenic diet. This study had a psychiatrist rate each twin’s symptoms while being unaware of their diet status. Interestingly, only when the patients were compliant with the diet did their symptoms improve. They also both lost weight. When they stopped the diet at the end of the study, their symptoms returned to their baseline level.
Stan's comments: - who were the medical criminals who stopped their patients' treatment as the article described, in spite of the clear improvement and despite of no viable alternatives? Why there was no information published and made available over the years, to other patients suffering from this debilitating disease, and their families? It is very symptomatic of a very serious disease rotting the medical system from within, in all countries. What have the government departments in charge of public health policies done to make that treatment available? Why did the judicial system refrain from punishing the people involved in maintaining this information hidden or even actively discouraging it by denigrating all ketogenic diets, all high fat low carbohydrate diets publicly and in the media? Who were the people, and who financed those who campaigned in the media smearing Drs. Yudkin, Atkins, Bernstein and others and why did public prosecutors and politicians allowed that to continue?
More connections between metabolic disorder and psychiatric/neurological conditions:
Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first episode psychosis (FEP) patients and unaffected siblings, compared to healthy individuals, using a physiological-based model and comprehensive assessment battery. Twenty-two unaffected siblings, 18 FEP patients and 15 healthy unrelated controls were evaluated using a 2-hour oral glucose tolerance test (OGTT), with 7 samples of plasma glucose and serum insulin concentration measurements. Insulin sensitivity was quantified using the oral minimal model method. Lipid, leptin, free fatty acids and inflammatory marker levels were also measured. Anthropometric, nutrient and activity assessments were conducted; total body composition and fat distribution were determined using whole-body dual energy x-ray absorptiometry. Insulin sensitivity significantly differed among groups (F=6.01, P=0.004), with patients and siblings showing lower insulin sensitivity, compared to controls (P=0.006, and P=0.002, respectively).
Comment: Comparison between people diagnosed with psychiatric disorder and their sibling who were not diagnosed and therefore not affected by psychiatric drugs, showed the common underlying metabolic disorder involving insulin insensitivity and high risk of developing diabetes type 2.
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Update 11/04/2019 Another interesting paper on this subject. A different angle:
Those mice that received the transplants from schizophrenic patients had higher levels of glutamine in the serum and hippocampus, decreased glutamate in the hippocampus, and increased GABA in the hippocampus. These difference were localized to areas of the brain particularly rich in glutamate and its metabolites (i.e., the outer shell of the brain and the hippocampus). This means that a transplant of a different microbiome led to different GABA-glutamate-glutamine neurotransmission in mouse brains. Corresponding human brain areas are related to memory, neuron repair, and executive functioning, all significantly impacted in schizophrenia.
In addition, the schizophrenia microbiome recipient mice had different behaviors than the healthy control mice, with exaggerated startle response and increased activity.
In this study, we used human renal cortical epithelial (HRCE) cells. The anti-apoptotic effect of βOHB was evaluated using flow cytometry analysis. The expression of apoptosis-related proteins and HDACs was evaluated by western immunoblot.
Key findings
The results showed that βOHB significantly reduced cisplatin-induced apoptosis in HRCE cells. Furthermore, βOHB significantly reduced cisplatin-induced cleavage of caspase-3, acetylation of histone H3, and phosphorylation of AMP-activated kinase. This anti-apoptotic effect of βOHB was markedly attenuated by an inhibitor of HDAC4/5, and βOHB-mediated suppression of cleavage of caspase3 was significantly blocked by siRNA-induced gene silencing of HDAC5.
Significance
βOHB attenuates cisplatin-induced apoptosis by activation of HDAC5 in HRCE cells, suggesting that βOHB may be a new therapeutic agent for cisplatin nephropathy.
Diabetes is reversible. That’s the exciting conclusion of a study I’m leading at Indiana University Health.
Two hundred and sixty-two patients with type-2 diabetes recently completed one year of a clinical trial examining the impact of a low-carbohydrate diet, which limits foods like grains and pasta while boosting consumption of healthy fats like avocados and butter. The diet didn’t restrict calories.
...
A full 94 percent of patients on the low-carb intervention have been able to reduce or eliminate their need for insulin. For six in ten patients, average blood sugar levels fell so low that technically, they had reversed their diabetes.
... With conventional treatment regimens, according to a study in Diabetes Care, only 0.1 percent of patients achieve complete remission.
I had "dry eye" condition for 10 years in the 1990-ties. Nothing helped, no doctor had any clue how to fix it. Until in 07/1999 I switched to a HFLC diet & stayed on - it went away after a few weeks never to reoccur ever again!
Lead author Dr Marcia Otto, from the University of Texas, Houston, said: 'Our findings not only support, but also significantly strengthen, the growing body of evidence which suggests that dairy fat, contrary to popular belief, does not increase risk of heart disease or overall mortality in older adults.
'In addition to not contributing to death, the results suggest that one fatty acid present in dairy may lower risk of death from cardiovascular disease, particularly from stroke.'
Dietary guidelines in the US and UK recommend people people opt for low or no-fat dairy, however, the researchers warn such options are often high in sugar, which can drive heart disease.
SUMMARY.
The principal factor inhibiting the growth of bacteria in the urine from patients receiving the ketogenic diet is l-𝛃-hydroxybutyric acid. The activity of this substance increases in proportion to the acidity of the urine.
A decade-long study on 135 thousand participants, examined mortality risk versus macronutrients correlations, based on reported food-questionaires. The findings:
1) Higher carbohydrate intake was associated with 28% increased risk of total mortality (highest quintile 5 vs lowest quintile 1 category).
2) Higher intake of total fat was associated with 23% lower risk of total mortality (quintile 5 vs quintile 1).
3) Total fat and saturated and unsaturated fats were not significantly associated with risk of myocardial infarction or cardiovascular disease mortality.
Quote:
"Global dietary guidelines should be reconsidered in light of these findings."
They mock vegans and eat 4lb of steak a day: meet 'carnivore dieters'
An extreme, all animal-based diet is gaining followers in search of heightened productivity, mental clarity, and a boosted libido. But experts express doubts
Instagram: shawnbaker1967At 51 years of age I am well aware of the tremendous evidence that demonstrates maintaining as much lean muscle mass as possible is necessary to mitigate the risks of cardiovascular disease and promotes excellent metabolic health-I remain incredibly insulin sensitive with a fasting insulin of just 2.6 and maintain extremely low levels of inflammation with a hsCRPof on 0.6 and also have very low triglycerides levels of only 54- also my VO2max is also among the best in the world for my age based on my rowing capacity- it is the entire system and its overall function that best indicate health!
Unsurprisingly, wheat and carbohydrate-pushing Australian Medical Association and fake pardon - mainstream media slammed it with unsubstantiated accusations:
A new documentary by controversial celebrity chef Pete Evans which claims the paleo diet can treat chronic disease has been slammed by Australia's top doctors.
The film, The Magic Pill, claims people suffering from illnesses such as diabetes, cancer and autism can reduce their symptoms and reliance on prescription drugs by adopting the diet for just five weeks. Australian Medical Association president Michael Gannon has compared the documentary to controversial anti-vaccination film, Vaxxed, and said the two were competing 'in the awards for the films least likely to contribute to public health'. 'Elements of the discussion are just plain hurtful, harmful and mean,' Dr Gannon told The Daily Telegraph.
The AMA's outburst came after Evans stood by his outspoken views on the paleo diet during an interview on Channel Seven's Sunday Night program. 'This way of eating reverses Type 2 diabetes. And guess how quickly it takes? Six to eight weeks. Maybe three months,' he said.
Great Awakening has been going on for some time! I was regarded eccentric 19 years ago when I started eating this style - then I discovered that telling people to renounce the official "food pyramid" guidelines to cure their diseases was met with greater opposition than if I told them to renounce "Jesus". It is strange how people are addicted to carbs and to their diseases! You want to regain health - get rid of all that mainstream garbage!
- Because changing your nutrition away from plant and carbohydrate-based towards animal fat-based will alter the way you act and behave! You will be more rational, clearer, calmer, stronger and balanced! :)
- Because what you don't know may hurt you!
- Because following a dietary advise financed by some institutions whose purpose is to sell you their products might not be your best survival strategy! Ask yourself why is that?
- Because not everything that is tasty and sold to you is healthy, use reason and knowledge to discern!
- Because not every medical or health guideline you read (anywhere) has to be true nor may be intended to help you; surprisingly, it may instead be intended to help them!
- Because not everything the scientists believe to be "true", is true!
- Because some prominent public figures who until recently or even still to this day scare you from eating natural food high in animal fats, may not hesitate from sacrificing you and your health for their own purposes, that involve "money" and "power". Be safe and renounce these people!
Be skeptical of all dietary and medical theories including those that I may be recommending, always check them out and verify them yourself because your own life and health is at stake. If in doubt use logic, intuition and your heart!
Heretic
(Google the original article by the title "The case for eating steak and cream", The Economist website will allow it display that Nina Teicholz' article on your computer only up to 3 times).
Me first, then my wife and our four girls begun following the high animal fat, moderate protein low carb diet, based on dr. Jan Kwasniewski's "Optimal Diet", in July 1999, and stayed on it ever since. Initially I started it a fact finding mission after one of our friends enthusiastically recommended it, saying that it cured his liver cirrhosis in 6 months!
Actually it did!
I couldn't believe it since it violated every common medical "wisdom" raining down on us from every media outlet, as well as all doctors we spoke to. I like that aspect... After two weeks I felt better, stronger, more energy, clearer thinking, no tiredness - better than I ever did since my 20-ties! In addition a number of ailments went away, for example dry eye condition, afternoon tiredness, persistent (but not acute) intestinal inflammation etc.
Then my wife and our children begun eating this style, then my mother who lived with us. She begun a month after me, begrudgingly after we ran out of bread since my wife stopped buying it. How my mom recovered her chronic health problems on the high fat diet and what exactly happened - that's another story! We continuet that eating style ever since. It works for us. Back in 1999 everybody thought I was crazy, they were seriously expecting me to drop dead withing months (which, to their surprise, did not happen!) When I begun my day job in 2009 half of my work colleagues were on some kind of "healthy" low fat salads and fruit for lunch or skim milk cereal diet, many were vegetarians (although there are fewer now) who wouldn't talk to me when I revealed my "orientation". Some still don't ! 😊
.
Is this possibly a cure for diabetes type 1 ? According to this BBC article and the quoted study, it may be so!
Interestingly, dr. Jan Kwasniewski , creator of the "Optimal Diet" has always claimed that such diet can virtually cure about 9 out of 10 of diabetes type 1, based on his personal patient's records from his own medical practice during 1970-ties and 1980-ties. The reason, according to him, is that in most cases, there are at least residual 10% of the pancreatic beta cells still intact allowing the patient to survive on the high fat diet, on about 6 insulin units per day, which is about 10% of the normal (on a high carb diet) insulin production. Such low insulin requirements is only attainable on a diet that is very low in carbohydrates, low in protein and therefore - high in fat. Dr. Kwasniewski always recommended to eat mostly animal fat and saturated fats, with a minimal to none contents of polyunsaturated vegetable oils. This is interesting because that was back in the days when the negative impact of polyunsaturated oils upon health was not as widely known as it is now. I always admired his medical insights ever since I learned about and adopted his diet in 1999. Since I don't normally trust opinions and always try to "touch the wound", so to speak, I always made efforts to verify and test all his claims. Every time when I thought he may have been wrong about some details such as vegetable fats issue or his preference on saturated fats, or insistence that cholesterol is a good thing and egg yolks are the best food (back in the 1970-ties!) - sooner or later he turned out to have been correct!
Results: ...The most significant dietary correlate of low CVD risk was high total fat and animal protein consumption. Additional statistical analyses further highlighted citrus fruits, high-fat dairy (cheese) and tree nuts. ... The major correlate of high CVD risk was the proportion of energy from carbohydrates and alcohol, or from potato and cereal carbohydrates.
Conclusion: Our results do not support the association between CVDs and saturated fat, which is still contained in official dietary guidelines. Instead, they agree with data accumulated from recent studies that link CVD risk with the high glycaemic index/load of carbohydrate-based diets. In the absence of any scientific evidence connecting saturated fat with CVDs, these findings show that current dietary recommendations regarding CVDs should be seriously reconsidered.
(CVD stands for "Cardio Vascular Disease")
by Cecilia Bleszynski (C) 2017
The first graph published in the paper:
is the most interesting in conjunction with the rest of the results, showing that the high consumption of animal fat and protein correlates very well with high blood cholesterol level and at the same time (see for example Fig.4 and 7) the high cholesterol and high consumption of animal fat and protein correlate consistently and strongly with the low cardiovascular and other diseases' risk! That is yet another nail to the coffin of the cholesterol-heart hypothesis and an indication that the blood cholesterol correlation with cardiovascular disease (+ or -) is secondary and spurious while the primary risk factor appears to be related to the carbohydrate contents of the diet! Note that some of the graphs refer to women some for men but the actual correlation factors are similar for men and momen (see Table 1) with the exception of correlations involving BMI and smoking which are opposite for women and men (that is another interesting subject).
Most of the results point consistently and strongly, see for example Fig.10 towards the carbohydrates contents of the diet as being the strongest positive correlator with the cardiovascular disease risk, where as the animal and most plant fats correlate most negatively (that is being protective) against cardiovascular disease, see Table 1, with the notable exception of sunflower oil which correlates strongly and positively with the CVD.
It is also interestingly to notice a strong linear correlation graph with very low data scatter, between the prevalence of raised blood glucose and consumption of carbohydrates plus alcohol ('CA' variable), on Fig.9:
Although diabetes risk was not directly measured in the study, Fig.9 appears to indicate that diabetes risk may be steeply correlated to the total consumption of carbohydrates plus alcohol, and strongly inversely correlated with the consumption of animal fat and protein (see Table 1). For example an increase of the dietary carbohydrate+alcohol contents from 42% to 68% seems to increase the prevalence of high blood glucose (and thus probably diabetes risk as well) by a factor of 3!
The overall results of this study are also remarkably consistent with the original China Study data as published on the Oxford University web site and discussed on this blog (see my previous posts).
The study is also discussed in the following journalistic article:
Each additional 5% of saturated fat (SFA) contents was associated with 17% lower risk of ischemic heart disease (IHD) : Hazard Ratio 0.83 +/- 0.1.
RESULTS:
During 12 y of follow-up, 1807 IHD events occurred. Total SFA intake was associated with a lower IHD risk (HR per 5% of energy: 0.83; 95% CI: 0.74, 0.93). Substituting SFAs with animal protein, cis monounsaturated fatty acids, polyunsaturated fatty acids (PUFAs), or carbohydrates was significantly associated with higher IHD risks (HR per 5% of energy: 1.27-1.37). Slightly lower IHD risks were observed for higher intakes of the sum of butyric (4:0) through capric (10:0) acid (HRSD: 0.93; 95% CI: 0.89, 0.99), myristic acid (14:0) (HRSD: 0.90; 95% CI: 0.83, 0.97), the sum of pentadecylic (15:0) and margaric (17:0) acid (HRSD: 0.91: 95% CI: 0.83, 0.99), and for SFAs from dairy sources, including butter (HRSD: 0.94; 95% CI: 0.90, 0.99), cheese (HRSD: 0.91; 95% CI: 0.86, 0.97), and milk and milk products (HRSD: 0.92; 95% CI: 0.86, 0.97).
Interestingly, equal-caloric substitution of 5% of SFA in the diet with:
any carbohydrate type (low GI, medium GI or high GI),
mono-unsaturated fats,
polyunsaturated fats,
animal protein,
- correlated positively with IHD, while substitution of SFA with vegetable protein correlated negatively! (Correlation calculations were corrected against known confounding factors such as age, sex, BMI, waist circumference, educational level, physical activity level, smoking status, alcohol intake, energy-adjusted intakes of cholesterol, fiber, and vitamin C.
A better title would have been "Money and greed trump medical lies and stupidity"
I shall better be kind to the bankers, some of them are on our side!
8-:)
Credit Suisse Investor's report (a short summary titled The Real Skinny on Fat is available on The Financialist page) concludes that saturated and monounsaturated animal fat is healthy and was unjustifiably blamed for the health problems that were in fact more likely caused by the overconsumption of vegetable polyunsaturated oils and carbohydrates. The institute's report is thus advising to invest in natural food producers selling product rich in saturated fats.
And the low carbohydrate (or low glucose) nutrition appears to contribute to longevity by increasing the SIRT6 activity (*), according to this paper, from the same issue of The Scientist magazine:
Perhaps the best evidence for the retrotransposon’s role in aging comes from the link between the activity of a longevity gene, SIRT6, and the repression of L1 in somatic tissues. SIRT6 encodes an enzyme critical to the forestallment of aging: it maintains telomere length, promotes DNA repair, regulates metabolism, opposes tumorigenesis, and attenuates inflammation—all processes associated with the prevention of age-related decline. Mice lacking SIRT6 suffer from a severe premature aging syndrome, while mice that overexpress SIRT6 enjoy extended life spans.
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One explanation for this failure may relate to SIRT6’s critical role in DNA repair. Several studies have indicated that SIRT6 helps catalyze repair of the damage at numerous types of DNA lesions, including single- and double-strand breaks. A characteristic feature of aging cells is an increase in the amount of DNA damage.
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While overexpression of SIRT6 may not be tractable in a therapeutic context, SIRT6 activity can be increased by caloric restriction, reducing glucose consumption, or increasing NAD+ bioavailability (**) - interventions that have already shown promise in increasing longevity in animal models. (Such interventions are also showing promise in slowing the progress of some age-related neurodegenerative disorders.
Notes:
*) Underexpression or removal of SIRT6 gene is linked to accelerated aging disease, while overexpression of SIRT6 has been shown to extend the lifespan, in mice studies, see Wiki.
**) Niacin is one of the precursors of NAD+, another one is tryptophan.
My current research project is Clifford Algebra. My current engineering work involves embedded software and hardware design of high end audio preamps and amplifiers for Bryston/Axiom. My old engineering projects: (hires)
(website), (old picture of my lab). My old consulting company: website and resume. This blog contains also the essays, articles and debates on human nutrition (high animal fat low carb since 1999), science and other interesting topics and heresies (all of which hugely beneficial). I welcome debates and discourage conformity of any kind. Other interesting topic: human -to-primate social regression mediated by regressive collectivism (link), and fraud cases in medical and other research.
The Quantum Time Machine (A QI-Themed Short Story)
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Dr Filius Apry had realised years ago, something that no-one else had:
Heisenberg's uncertainty principle allows time travel. Well... sort of. To
avoid b...
The Quantum Time Machine (A QI-Themed Short Story)
-
Dr Filius Apry had realised years ago, something that no-one else had:
Heisenberg's uncertainty principle allows time travel. Well... sort of. To
avoid b...
Climate Attribution In Greece
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Climate scientists have determined that the fires in Greece this summer
were caused by the burning of fossil fuels, rather than the hundreds of
arsonists w...
7 Reasons Why Your Tech Blog Isn’t Succeeding
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It is exciting to start a tech blog. Your mind projects thousands of
visitors to your site on a daily basis, and reads your reviews on new tech
devices, pr...
Protons (82) Size matters
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Here's the next paper:
Obese adipocytes show ultrastructural features of stressed cells and die of
pyroptosis
I would suggest that the first of many probl...
The Cover up – Part One (context)
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The Cover-up – Part One (context) A cover up. Yes, I know, I have
repeatedly said that I do not believe there was a great world-wide
conspiracy around COVI...
there is no “reset” – just live forward!
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If you’re an intense person by nature, it’s likely that up to 75% of your
life energy every minute, every hour, every day is automatically…
The Prostate and its Discontents
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This post originally appeared for subscribers only on my Patreon blog
(October 31). If you appreciate my occasional writing on science and stuff subscribe...
Akathisia
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I recently recorded an episode of my podcast with my dad Jordan Peterson to
talk about what happened to him and my family in the last year. The
following...
Iron: an underrated factor in aging
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My article, “Iron: an underrated factor in aging” has been published by the
journal Aging. The abstract: Iron is an essential element for virtually all
l...
Farewell, for now
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“Ah, what an age it is When to speak of trees is almost a crime For it is a
kind of silence against injustice.” –Bertolt Brecht (1898-1956) In my
professio...
Leaving Facebook After ~11 years
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This past week my wife and I engaged in the following activity:
#deletefacebook
Here’s excepts from text shared with friends and family:
You are being f-...
Twitter jail!
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Well hello everyone :)
I have not blogged in a year! Feels rather odd to be honest; and to think,
this used to be MY platform.
While i have been consider...
Warning to Gay and Lesbian Movements
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*Warning to Gay and Lesbian Movements.*
(Polish version - see below. Wersja Polska - poniżej)
As LGBT movement became radicalized and more visible than ever...
Ketosis Without Starvation: the human advantage
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I recently had the honour to speak at Low Carb Breckenridge 2018. You can
find the video here. Below are my slides, notes, and references.
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Fasting Insulin
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A blood test for fasting insulin can be one of the most important that you
get. It’s important because it shows the degree of insulin resistance: […]
Delegalize compulsory purchase of all types of insurance, including car and health service!
Delegalize health overseeing authorities and ban anti-competitive practices in the health services!
Delegalize manipulation of interest rate that robs the savers and enriches the large banks and governments.
Down with the dictate of shallow superficial people!
A critical period for children's education is age 7-14. Anything they learn during that period will be "weaponized" for the rest of their lives. Do not let them socialize during this period. Slow down their puberty past the age of 14 using low carb high animal fat diet!
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Lunar Calendar 13
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Moon Calendar: 13 months of 4 weeks of 7 days
Upper table: normal calendar dates (red numbers)
and the corresponding Moon Calendar dates (black) and (blue)
Lower table: Moon Months (1-13) and Moon Calendar dates
