"Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports." Nebeling LC, Miraldi F, Shurin SB, Lerner E.
"Targeting energy metabolism in brain cancer: review and hypothesis", Thomas N Seyfried and Purna Mukherjee, Nutrition & Metabolism 2005,2:30
"Can a High-Fat Diet Beat Cancer?"
By Richard Friebe Monday, Sep. 17, 2007
And finally a paper from my favored scientific publisher specializing in printing fake peer-review journals:
"Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet" Catherine J. Chu-Shore, Elizabeth A. Thiele
Three out of five patients, all children, had progression of a known tumor or tumors or the development of a new tumor while on the ketogenic diet. Conclusion: In this limited case series of five TSC patients, the ketogenic diet did not induce tumor regression or suppress the growth of TSC-related tumors.
I am curious, if they emphasize that it didn't help the 3 out of 5, should we interpret it as stating that it did help the other 2 out of 5? (I do not have the access to the full paper to check it).
Footnote (for an oncologist with a PhD's)
No, it does not work (if it works) by starving a cancer through lowering serum glucose level down to zero. Yes it would of course have killed a patient together with a tumor.
What the ketogenic diet does do is it totally alters a body's predominant metabolic mode shifting it from glucose to ketone bodies and lipids. One side effect of ketogenic diets is the enhancement of the immune system (we all heard of course, I presume of the standard pre-penicillin therapy against TB...)
Another effect is reduction of glucose uptake by the healthy cells that are not yet cancerous and the protective effect resulting from much lower insulin production (and insulin tissue uptake) on the true ketogenic diet versus a low fat high carbohydrate diet. Another and probably even more important effects are those that we do not yet fully understand due to a curious lack of curiosity or competence of some oncologists with the PhD who do not seem to want to pursue any investigation that might actually work...
Based on my mom's experience, the best survival strategy is to listen carefully to the oncologists, write thoroughly down everything they have to say - and do the opposite! It has worked well for my mom since her close encounter with the disease in 1998 when she refused a friendly "slash-burn-and-poison" therapy offer from her local hospital. Eleven years later, so far so good...
Be free and prosper,
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More references (thanks Cynthia):
"Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2."
Fine EJ, Miller A, Quadros EV, Sequeira JM, Feinman RD.
CONCLUSION: Seven human cancer cell lines grown in glucose plus acetoacetate medium showed tightly coupled reduction of growth and ATP concentration. The findings were not observed in control fibroblasts. The observed over-expression of UCP2 in cancer lines, but not in controls, provides a plausible molecular mechanism by which acetoacetate spares normal cells but suppresses growth in cancer lines. The results bear on the hypothesized potential for ketogenic diets as therapeutic strategies.
Read Peter's post: Methylglyoxal on Atkins...
The story can be compressed into two titles:
Ketosis leads to increased methylglyoxal production on the Atkins diet.
A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients.
Carbohydrates and the Risk of Breast Cancer among Mexican Women
Starch Intake May Influence Risk for Breast Cancer Recurrence, Jennifer A. Emond, M.S.
Abstract Number: P3-09-01, San Antonio Breast Cancer Symposium, 2011, Title: Change in Carbohydrate Intake and Breast Cancer Prognosis.
Is there a role for carbohydrate restriction in the treatment and prevention of cancer?
Rainer J Klement and Ulrike Kämmerer