.Low dose ( below 4.5mg, standard dose is 200mg ) of anti-opiod addiction drug Naltrexone found to have also anti-cancer property!
Professor of Oncology, Angus Dalgleish gives vital information on a repurposed drug he uses for his cancer patients, given at a very low dose. This is Low Dose Naltrexone.
Quote: Since inhibition of SERCA is a mechanism of action that has been used to target solid tumors, thapsigargin has attracted research interest. A prodrug of thapsigargin, mipsagargin, is currently undergoing clinical trials for the treatment of glioblastoma.
... The task has been taken on by Samuel Denmeade, an oncologist at Johns Hopkins University in Baltimore. He and his team spent 15 years engineering an analogue of thapsigargin, the active ingredient in the plant, to fight cancer cells exclusively. Thapsigargin typically works by passing through cell membranes and shutting down calcium pumps – essential for cell survival – on the inside of cells. Denmeade’s team modified the thapsigargin molecule by adding an extra peptide chain which prevents the toxin from entering cells. That is, until it encounters PSMA – an enzyme commonly found on the surface of many prostate cancer cells. PSMA cleaves the extra chain off the toxin, setting it free to do its devastating business. Precision killer While traditional chemotherapy drugs only target cells undergoing rapid growth, this new toxin is a generalist, destroying not just the cancer cells currently growing, but also those lying dormant as well as non-cancer cells recruited to help the tumour grow. ...
Introduction. So called “optimal diet” – a low-carbohydrate, high-fat
diet, different from Atkins diet – has become very popular in Poland
during the last 20 years. It is very controversial; official dietetics in
Poland claim it is extremely noxious.
Aim [Objectives]. To check what are the effects of so-called “optimal diet” on
health status, frame of mind of people, their physical activity and
diseases including type 2 diabetes.
Material and methods. 436 persons aged 20-75 years, both
women (247) and men (189) were examined. 231 of them applied
“optimal diet” and 205 did not. 86 confirmed they suffered from
type 2 diabetes. All examined persons were inquired with our own
questionnaire.
Results. Quite a lot of statistically significant dependencies were
found to exist. They show us that persons applying the “optimal
diet” might be physically active longer than the persons not applying
it. The majority of the “optimal diet” users claim they got rid of
overweight owing to this diet. Quite many of them claim they
cured themselves of the diabetes or at least the diabetes distress
has distinctly diminished.
Conclusions. The persons applying the “optimal diet” claim they
got rid of overweight or even cured themselves of the diabetes
owing to the diet. Our data do seem to confirm the last reports
(Al-Khalifa et al. 2009).
"Over half of the respondents were able (in their opinion)-----
to heal themselves of diabetes using the so-called optimal diet [OD], but it was not possible for anyone (according to respondents' opinions) who did not follow the OD."
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No beneficial relationship was found between LDL-C lowering and cardiovascular events explored by meta-regression; instead, there was a trend toward harm.
CONCLUSIONS: The relationship between LDL-C lowering and cardiovascular events has not showed any significant association (and even a tendency toward harm), challenging the "lower the better" theory. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients has showed a tendency to harm for all outcomes with PCSK9 antibodies. Therefore, at the moment, the data available from randomized trials does not clearly support the use of these antibodies.
Findings
During follow-up, we documented 5796 deaths and 4784 major cardiovascular disease events. Higher carbohydrate intake was associated with an increased risk of total mortality (highest [quintile 5] vs lowest quintile [quintile 1] category, HR 1.28 [95% CI 1.12–1.46], ptrend=0.0001) but not with the risk of cardiovascular disease or cardiovascular disease mortality. Intake of total fat and each type of fat was associated with lower risk of total mortality (quintile 5 vs quintile 1, total fat: HR 0.77 [95% CI 0.67–0.87], ptrend<0.0001; saturated fat, HR 0.86 [0.76–0.99], ptrend=0.0088; monounsaturated fat: HR 0.81 [0.71–0.92], ptrend<0.0001; and polyunsaturated fat: HR 0.80 [0.71–0.89], ptrend<0.0001). Higher saturated fat intake was associated with lower risk of stroke (quintile 5 vs quintile 1, HR 0.79 [95% CI 0.64–0.98], ptrend=0.0498). Total fat and saturated and unsaturated fats were not significantly associated with risk of myocardial infarction or cardiovascular disease mortality.
Compared with people who ate the lowest 20 percent of carbohydrates, those who ate the highest 20 percent had a 28 percent increased risk of death. But high carbohydrate intake was not associated with cardiovascular death.
People with the highest 20 percent in total fat intake - an average of 35.3 percent of calories from fat - had about a 23 percent reduced risk of death compared with the lowest 20 percent (an average of 10.6 percent of calories from fat). Consuming higher saturated fat, polyunsaturated fat and monounsaturated fat were all associated with lower mortality. Higher fat diets were also associated with a lower risk of stroke.
A study by Bristol University of almost 10,000 men in the south west of England found that those who gave up meat were almost twice as likely to suffer depression as those on a conventional balanced diet. It found the 350 committed vegetarians had a higher average depression score compared to others.
The paper, in the Journal of Affective Disorders, said a veggie diet led to lower intake of vitamin B12 and greater consumption of nuts rich in omega-6 fatty acids, which may be linked with greater risk of mental health problems. The report added: ‘Other potential factors include high blood levels of phytoestrogens – consequent mainly on diets rich in vegetables and soya. Another potential contributing factor is that lower intakes of seafood are thought to be associated with greater risk of depressive symptoms.’ Around one in 20 Britons are committed vegetarians and the majority are women.
Researchers in the US studied the impact of drugs on patients with breast cancer and found medication increases the chance of cancer cells migrating to other parts of the body, where they are almost always lethal.
Many are given chemotherapy before surgery, but the new research suggests that, although it shrinks tumours in the short term, it could trigger the spread of cancer cells around the body.
It is thought the toxic medication switches on a repair mechanism in the body which ultimately allows tumours to grow back stronger. It also increases the number of ‘doorways’ on blood vessels which allow cancer to spread throughout the body.
Dr George Karagiannis, of the Albert Einstein College of Medicine of Yeshiva University, New York, found the number of doorways was increased in 20 patients receiving two common chemotherapy drugs.
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| Wiki Salt |
The research was carried out by investigators at McMaster University and Hamilton Health Sciences.
They analyzed more than 130,000 people across 49 countries, focusing on whether the relationship between sodium (salt) intake and death, heart disease and stroke differs in people with high blood pressure compared to those with normal blood pressure.
Their findings showed that regardless of whether people have high blood pressure, low-salt intake is linked to a greater incidence of heart attacks, stroke, and deaths compared to average intake.
...
Dr Mente said that this suggests that the majority of individuals in Canada and most countries are consuming the right amount of salt.
He added that targeted salt reduction in those who are most susceptible because of hypertension and high salt consumption may be preferable to a population-wide approach to reducing sodium intake in most countries except those where the average sodium intake is very high, such as parts of central Asia or China.
He added that what is now generally recommended as a healthy daily ceiling for sodium consumption appears to be set too low, regardless of a person's blood pressure level.
'Low sodium intake reduces blood pressure modestly, compared to average intake, but low sodium intake also has other effects, including adverse elevations of certain hormones which may outweigh any benefits,' Dr Mente said.
'The key question is not whether blood pressure is lower with very low salt intake, instead it is whether it improves health.'
Dr Martin O'Donnell, a co-author on the study and an associate clinical professor at McMaster University and National University of Ireland Galway, said: 'This study adds to our understanding of the relationship between salt intake and health, and questions the appropriateness of current guidelines that recommend low sodium intake in the entire population.'
The study was funded from more than 50 sources, including the PHRI, the Heart and Stroke Foundation of Canada and the Canadian Institutes of Health Research.
While the Brazilian government rushes to blame the Zika virus for this huge rise in abnormal birth defects, causation remains unclear. Only a small number of babies with birth defects, who died, had the virus in their brain or in the mother’s placenta. This means a large number of the babies who died had no Zika virus in their brain. Hard to blame Zika then, which has been around since before 1948 and has never been known to cause birth defects and/or death. In fact, Zika makes only one in five people get “mildly” sick with flu-like symptoms, with no symptoms at all in 4 out of 5 people. So why are they quick to blame a generally benign Zika virus?
In late 2014, the Brazilian minister of health announced that a new Tdap shot would be mandatory for all expectant mothers starting in 2015. Since it’s mandatory, mothers with birth defect babies received this newly formulated vaccine while pregnant. The timeliness of the Tdap vaccine and the sudden rise in birth defects is more than just a little coincidental. The consequences of this untested vaccine is being swept under the rug.
The truth is that the Tdap shot has never been proven safe for use during pregnancy. In fact, Tdap is classified by the FDA as a Class C drug.
The definition of a Class C drug which is how the Tdap shot is classified:
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
--USE IN SPECIFIC POPULATIONS----
Safety and effectiveness of Adacel vaccine have not been established in pregnant women. (8.1)
* from Advisory Committee on Immunization Practices (ACIP) Summary Report February 23-24, 2011 minutes (p. 34-35)
"From January 1, 2005 through June 30, 2010, of 10,350 reports after Tdap vaccines, 129 involved pregnant women who submitted a report to VAERS. Although there were reports of 20 spontaneous abortions, 2 stillbirths, and 2 congenital anomalies, VAERS is not designed to assess whether a vaccine caused an adverse event. A review of VAERS reports in pregnant women who received Tdap vaccines revealed no elevated frequency or unusual patterns. Both GSK and sanofi pasteur maintain vaccination pregnancy registries to collect data on pregnancy outcomes and newborn health status outcomes following vaccination. Both were kind enough to allow Dr. Liang to present on their behalf. The work group reviewed their data in detail, and she provided the summary points. Boostrix® was licensed in 2005 for 10 through 18 year olds, and in 2008 for adults. GSK maintains a registry to collect data on pregnancy outcomes and newborn health status outcomes following vaccination. From its U.S. market launch in 2005 through August 2, 2010, 33 pregnancies were prospectively registered. Of these pregnancies, 18 were lost to follow-up. Outcomes were reported for seven pregnancies, and consisted of six live infants born without birth defects and one spontaneous abortion at seven weeks gestation. The remaining eight pregnancies were on-going at the time of last contact. In addition to the prospective reports of pregnancy received to the pregnancy registry from the U.S., GSK has received 13 reports from other countries. Just over half of these reported normal outcomes. The rest are on-going or were lost to follow-up. There have been no birth defects after Boostrix® vaccination reported to GSK."
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| From Wiki |
RESULTS:
During 12 y of follow-up, 1807 IHD events occurred. Total SFA intake was associated with a lower IHD risk (HR per 5% of energy: 0.83; 95% CI: 0.74, 0.93). Substituting SFAs with animal protein, cis monounsaturated fatty acids, polyunsaturated fatty acids (PUFAs), or carbohydrates was significantly associated with higher IHD risks (HR per 5% of energy: 1.27-1.37). Slightly lower IHD risks were observed for higher intakes of the sum of butyric (4:0) through capric (10:0) acid (HRSD: 0.93; 95% CI: 0.89, 0.99), myristic acid (14:0) (HRSD: 0.90; 95% CI: 0.83, 0.97), the sum of pentadecylic (15:0) and margaric (17:0) acid (HRSD: 0.91: 95% CI: 0.83, 0.99), and for SFAs from dairy sources, including butter (HRSD: 0.94; 95% CI: 0.90, 0.99), cheese (HRSD: 0.91; 95% CI: 0.86, 0.97), and milk and milk products (HRSD: 0.92; 95% CI: 0.86, 0.97).
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CHD
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diet
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fat
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The new research, published online in the British Medical Journal, was carried out by experts from the US Government’s National Institutes of Health in Maryland. They recovered missing data from a study in the 1960s involving 458 men aged 30-59 who had suffered a heart attack or angina. Using modern statistical methods to compare death rates, they found there was no evidence of the benefit of replacing saturated fats with omega-6 linoleic acid, found in vegetable fats. In fact, they said replacing the animal fats with polyunsaturated fatty acids (PUFAs) from vegetable fats increased risk of death in those patients with cardiovascular disease. Those who increased their intake of the “healthy” fats over three years were almost twice as likely to die. The omega-6 linoleic acid group in the study had a higher risk of death from all causes (62 per cent), as well as from cardiovascular disease (70 per cent) and coronary heart disease (74 per cent), compared to others. Linoleic acid is present in high amounts in some commonly used vegetable oils such as corn, sunflower, safflower and soya bean.
...
Advice to substitute vegetable oils rich in polyunsaturated fatty acids (PUFAs) for animal fats rich in saturated fatty acids (SFAs) has been a cornerstone of worldwide dietary guidelines for the past half century.1 When this advice originated in the 1960s, PUFAs were regarded as a uniform molecular category with one relevant biological mechanism—the reduction in blood cholesterol.1 2 Omega 6 (n-6) linoleic acid (LA) was the best known dietary PUFA at the time.
...
Diet intervention
The intervention group received instructions to increase their PUFA intake to about 15% of food energy, and to reduce their intake of SFA and dietary cholesterol to less than 10% of food energy and 300 mg per day, respectively.10 To achieve these targets, intervention participants were provided with liquid safflower oil and safflower oil polyunsaturated margarine (“Miracle” brand, Marrickville Margarine). Liquid safflower oil was substituted for animal fats, common margarines and shortenings in cooking oils, salad dressings, baked goods, and other products, and was also taken as a supplement. Safflower oil polyunsaturated margarine was used in place of butter and common margarines.
Control
The control group received no specific dietary instruction. However, some participants began substituting polyunsaturated margarine for butter after their coronary event.33 Because the research team made no effort to alter the PUFA or SFA content of control diets, such dietary changes were allowed to continue.
...
In this cohort, substituting dietary linoleic acid in place of saturated fats increased the rates of death from all causes, coronary heart disease, and cardiovascular disease. An updated meta-analysis of linoleic acid intervention trials showed no evidence of cardiovascular benefit. These findings could have important implications for worldwide dietary advice to substitute omega 6 linoleic acid, or polyunsaturated fats in general, for saturated fats.[IF THEY HAD BEEN PUBLISHED RATHER THAN GONE MISSING, AT THE TIME, FOURTY YEARS AGO!]
...
Increased all cause mortality in the safflower oil group was reported in 1978,10 although deaths due to cardiovascular disease and coronary heart disease were not reported by group.[BECAUSE THE DATA WENT MISSING!] Clinical outcomes for cardiovascular disease and coronary heart disease have been considered to be more relevant than all cause mortality when evaluating the evidence base25 and formulating dietary guidelines.26 Therefore, previous meta-analyses of PUFA intervention trials and risk of cardiovascular disease25 27 28 have been incomplete because they were not able to include these missing data from the SDHS. [SDHS=SYDNEY DIET HEART STUDY. CONCIDENTALLY, THE MISSING HEART MORTALITY DATA HAPPENED TO CONTRADICT, BY A LARGE FACTOR, THE EXPECTED OUTCOME! HAD THE HEART MORTALITY DATA NOT GONE "MISSING" FOURTY YEARS AGO, THE ENTIRE VEGETABLE OIL INDUSTRY WOULD PROBABLY NOT EXIST BY NOW!]
As expected, increasing n-6 LA from safflower oil in the SDHS significantly reduced total cholesterol; however, these reductions were not associated with mortality outcomes (results not shown). Moreover, the increased risk of death in the intervention group presented fairly rapidly and persisted throughout the trial. These observations, combined with recent progress in the field of fatty acid metabolism, point to a mechanism of cardiovascular disease pathogenesis independent of our traditional understanding of cholesterol lowering.
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| Fig.2 (bottom) from the study. |
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Thapsia garganica
