.The data is not fully verified. I used the reference links and borrowed some words from this post Comment by Captain Sunset on Hyperlipid
Sunday, February 13, 2022
Pfoizon's postmarketing experience
Saturday, January 15, 2022
Wednesday, December 22, 2021
The Lancet paper on Ivermectin
The study found no difference between the treated group versus the control group in the viral load detected by PCR, but treated patients recovered twice as fast.
Title: "The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial", by Carlos Chaccour et al., The Lancet, January 19, 2021
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30464-8/fulltext
Friday, December 10, 2021
The Lancet article on c19 spread by vac people
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An article published by Günter Kampf in The Lancet, Letters, 19-Nov-2021.
Quote:
High COVID-19 vaccination rates were expected to reduce transmission of SARS-CoV-2 in populations by reducing the number of possible sources for transmission and thereby to reduce the burden of COVID-19 disease. Recent data, however, indicate that the epidemiological relevance of COVID-19 vaccinated individuals is increasing. In the UK it was described that secondary attack rates among household contacts exposed to fully vaccinated index cases was similar to household contacts exposed to unvaccinated index cases (25% for vaccinated vs 23% for unvaccinated). 12 of 31 infections in fully vaccinated household contacts (39%) arose from fully vaccinated epidemiologically linked index cases. Peak viral load did not differ by vaccination status or variant type [[1]]. In Germany, the rate of symptomatic COVID-19 cases among the fully vaccinated (“breakthrough infections”) is reported weekly since 21. July 2021 and was 16.9% at that time among patients of 60 years and older [[2]]. This proportion is increasing week by week and was 58.9% on 27. October 2021 (Figure 1) providing clear evidence of the increasing relevance of the fully vaccinated as a possible source of transmission. A similar situation was described for the UK. Between week 39 and 42, a total of 100.160 COVID-19 cases were reported among citizens of 60 years or older. 89.821 occurred among the fully vaccinated (89.7%), 3.395 among the unvaccinated (3.4%) [[3]]. One week before, the COVID-19 case rate per 100.000 was higher among the subgroup of the vaccinated compared to the subgroup of the unvaccinated in all age groups of 30 years or more. In Israel a nosocomial outbreak was reported involving 16 healthcare workers, 23 exposed patients and two family members. The source was a fully vaccinated COVID-19 patient. The vaccination rate was 96.2% among all exposed individuals (151 healthcare workers and 97 patients). Fourteen fully vaccinated patients became severely ill or died, the two unvaccinated patients developed mild disease [[4]]. The US Centres for Disease Control and Prevention (CDC) identifies four of the top five counties with the highest percentage of fully vaccinated population (99.9–84.3%) as “high” transmission counties [[5]]. Many decisionmakers assume that the vaccinated can be excluded as a source of transmission. It appears to be grossly negligent to ignore the vaccinated population as a possible and relevant source of transmission when deciding about public health control measures.
Sunday, November 28, 2021
AHA paper on cov. vac. - dramatic increase of cardiac risk markers
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Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning
Our group has been using the PLUS Cardiac Test (GD Biosciences, Inc, Irvine, CA) a clinically validated measurement of multiple protein biomarkers which generates a score predicting the 5 yr risk (percentage chance) of a new Acute Coronary Syndrome (ACS). The score is based on changes from the norm of multiple protein biomarkers including IL-16, a proinflammatory cytokine, soluble Fas, an inducer of apoptosis, and Hepatocyte Growth Factor (HGF)which serves as a marker for chemotaxis of T-cells into epithelium and cardiac tissue, among other markers. Elevation above the norm increases the PULS score, while decreases below the norm lowers the PULS score.The score has been measured every 3-6 months in our patient population for 8 years. Recently, with the advent of the mRNA COVID 19 vaccines (vac) by Moderna and Pfizer, dramatic changes in the PULS score became apparent in most patients.This report summarizes those results. A total of 566 pts, aged 28 to 97, M:F ratio 1:1 seen in a preventive cardiology practice had a new PULS test drawn from 2 to 10 weeks following the 2nd COVID shot and was compared to the previous PULS score drawn 3 to 5 months previously pre- shot. Baseline IL-16 increased from 35=/-20 above the norm to 82 =/- 75 above the norm post-vac; sFas increased from 22+/- 15 above the norm to 46=/-24 above the norm post-vac; HGF increased from 42+/-12 above the norm to 86+/-31 above the norm post-vac. These changes resulted in an increase of the PULS score from 11% 5 yr ACS risk to 25% 5 yr ACS risk. At the time of this report, these changes persist for at least 2.5 months post second dose of vac.We conclude that the mRNA vacs dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination.


Thursday, October 14, 2021
Scotland-UK gov report for Aug-Sep shows v. have very little effect on c. deaths
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It is interesting to note that "The Age Standardised Mortality Rate per 100,000" figures given in Table 18 (i.e. 8.38, 4.93, 1.93 for the unv., 1-va and 2-va, for the 11-17 of September) are inconsistent with the population va rates and the number of deaths in each category. These rates are probably adjusted and corrected for other factors. Unfortunately they did not explain (or I missed it) how exactly they were adjusted and corrected.That's why I re-ran the numbers myself to verify them. I took the number of unv'ed people who died of c. (59) in the period, dividing them by the total number of people who died of c. (59+10+233=302, that is the total of unv'ed plus 1-v'ed plus 2-v'ed who died). Divide 59 by 302 - you will get 20%. The actual percentage of those who died of c. and were double-v'ed is 77% (that is 233 by 302).
If you google the population stats for Scotland, for September, you will find that 22% are unv'ed, 78% are at least once v'ed (therefore 7% are exactly once-v.) and 71% are double v'ed.
To summarize it, 22% of the entire population are unv'ed and constitute 20% of those who died on c.
Double v'ed constitute 71% of the entire population and 77% of those who died on c.
Reference:
1/ SeeTable 18 in "Public Health Scotland C-XIX Statistical Report As at 27 September 2021"
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Table 18 (from the above-report) |
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Age-Standardised Mortality Rate referenced in Table 18. |
2/ C-XIX va. rates in Scotland, up to 10-Oct-2021, by Google search:
Wednesday, September 29, 2021
Vaccines and the innate and adaptive immune systems
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In 2005, Drs. Weissman and Kariko discovered a way to protect foreign mRNA from the body’s immune system. That scientific milestone would be key to the advancement of the mRNA vaccines in 2020.
Recently, the University of Pennsylvania Tweeted a picture of the Drs. Weissman and Kariko receiving their Covid vaccination, and reminding us of that milestone. One tweet commenting that they should receive the Nobel prize for their discovery.
The fundamental change discovered by Weissman and Kariko was that nucleoside modification could protect mRNA from the body’s immune defences:
Their key discovery, that by modifying the RNA code (modifying the nucleoside uridine), resulted in ablating the innate immune response, involved toll-like receptors (TLR).
This discovery was adopted in the mRNA technology used in Covid vaccines, in order that the foreign vaccine mRNA could enter cells without being destroyed.
...
By modifying the Uridine in the Pfizer vaccine mRNA code, the foreign mRNA is able to bypass part of the body’s first line of defence — the Innate Immune System.
The body possesses two broad parts to its immune system: innate and specific. The innate is the first to go into action against foreign invaders, including foreign mRNA from a vaccine.
How does that simple removal of one letter of code from mRNA achieve that? It does so by affecting Toll Like Receptors (TLR): the alarm signal of the Innate Immune System.
The key TLRs affected are TLR 3, TLR 7 and TLR 8. They act as sentries, whose job is to recognise foreign invaders by way of their form or patterns;
...
Dominguez-Andres et al addressed that question May 6th 2021. They state: ...
...
BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination.
...
We observed a significant reduction in the production if IFN-α secreted after stimulation with poly I:C and R848 after the administration of the second dose of the vaccine (Figure 1H, 1I). This may hamper the initial innate immune response against the virus, as defects in TLR7 have been shown to result in and increased susceptibility to COVID-19 in young males (Van Der Made et al., 2020). These results collectively demonstrate that the effects of the BNT162b2 vaccine go beyond the adaptive immune system and can also modulate innate immune responses.
Three concerns are raised by the above.
- The ability of the immune system to fight viruses has been diminished; specifically, the ability to fight SARS-CoV-2 may be affected;
- Vaccine-induced innate immune tolerance may affect other vaccines; and finally
- What other parts of the immune system may be affected.
...
Dr Ryan Cole, a Pathologist, in a recent presentation, stated that he is observing a 20 x uptick in endometrial cancer, and increases in other cancers post SARS-CoV-2 vaccination.
...
The toll-like receptors 7 & 8 are described in the literature as important in eliciting the vital CD8 T cell response. With that in mind, let us remind ourselves what Drs. Weissman and Kariko wrote in 2005 in Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA:
We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity.
That very technology is being used in SARS-CoV-2 vaccines: It switches off TLR 7 & 8 signalling, that the immune system needs to fight infection and cancer.
Summary
Changes to key parts of the mRNA code in SARS-CoV-2 vaccines may be causal in changing the innate immune response via toll-like receptors. Toll-like receptors are important components in defence against infection and downstream effects may also include inhibition of CD8 T cell response. CD8 is a vital part of the immune system’s ability to eradicate infection and cancer. Those changes may be reflected in recent reactivated Varicella Zoster infections although specific mechanisms are unclear at the moment. Anecdotal reports of significant uptick in cancer presenting to medical consultants may be consistent with aberrant toll-like receptor and dendritic cell changes leading to an inhibition of the anti-cancer CD8 effector response. Further data are required but the prospect of an altered CD8 response to infection and cancer is very concerning and should prompt urgent investigation.
...
Monday, September 27, 2021
smokers hospitalized less often for covid
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Smokers Hospitalized Less Often for COVID-19 By Carolyn CristThe hypothesis comes from Konstantinos Farsalinos, a cardiologist in Greece who focuses on tobacco-use reduction. Farsalinos noticed that few COVID-19 patients who were hospitalized in China were smokers, though about half of men in the country smoke.
Farsalinos and colleagues wrote a new paper available as a preprint and scheduled to be published in Internal and Emergency Medicine. They found that among 13 studies in China with nearly 6,000 hospitalized COVID-19 patients, the rate of smokers ranged from 1.4% to 12.6%. No studies recorded e-cigarette use.
“The results were remarkably consistent across all studies and were recently verified in the first case series of COVID-19 cases in the U.S.,” the authors wrote, calling for an “urgent investigation.”
Of course, Farsalinos doesn't recommend that people should begin smoking simply to attempt to avoid a severe case of COVID-19.
Saturday, September 25, 2021
Physical activity increases cardiovascular calcium score
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The results suggested an overreliance on calcium scores and imaging alone may not be the best way to assess cardiovascular risk, said Dr Brown, a consultant cardiologist.
Unfortunately I was not yet able to locate the original (Korean) study, I will post the link when I find it.
To explore the issue further, the researchers studied healthy adults attending for check-ups in South Korea over a six-year period.
Those who were more physically active tended to be older and less likely to smoke than less physically active participants. They also had lower total cholesterol, more high blood pressure, and existing evidence of calcium deposits in their coronary arteries.
An association between physical activity level and the prevalence and progression of coronary artery calcification emerged over time. Higher physical activity was associated with faster progression of calcification scores.
Experts said the new study may mean that exercise increases the risk of a heart attack, or it may be that calcium build-up is not a good measure of heart attack risk.
Curious lack of discussion on natural immunity
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"Why ''Natural Immunity'' Is A Political Problem For The Regime", by CD Media StaffSeptember 24, 2021Both the Mayo Clinic website and the Centers for Disease Control and Prevention website, for example, insist that “research has not yet shown” that people who have recovered from covid have any sort of reliable protection. Moreover, the CDC page points to a single study from Kentucky claiming that people with natural immunity are more than twice as likely to contract covid again, compared to people who have been vaccinated.
More than 15 studies have demonstrated the power of immunity acquired by previously having the virus. A 700,000-person study from Israel two weeks ago found that those who had experienced prior infections were 27 times less likely to get a second symptomatic covid infection than those who were vaccinated. This affirmed a June Cleveland Clinic study of health-care workers (who are often exposed to the virus), in which none who had previously tested positive for the coronavirus got reinfected. The study authors concluded that “individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.” And in May, a Washington University study found that even a mild covid infection resulted in long-lasting immunity.
The policy bias in favor of vaccines ignores many other facts as well, such as the relative risks of vaccines, especially for the young:
The current Centers for Disease Control and Prevention position about vaccinating children also dismisses the benefits of natural immunity. The Los Angeles County School District recently mandated vaccines for students ages 12 and up who want to learn in person. But young people are less likely to suffer severe or long-lasting symptoms from covid-19 than adults, and have experienced rare heart complications from the vaccines. In Israel, heart inflammation has been observed in between 1 in 3,000 and 1 in 6,000 males age 16 to 24; the CDC has confirmed 854 reports nationally in people age 30 and younger who got the vaccine. ...
... For comparison, the CDC has long recommended that kids do not get the chickenpox vaccine if they had chickenpox infection in the past.
The nonscientific, ideology-induced blind spot for natural immunity also prompted The BMJ (the journal of the British Medical Association) to note that “[w]hen the vaccine rollout began in mid-December 2020, more than one quarter of Americans—91 million—had been infected with SARS-CoV-2…. As of this May, that proportion had risen to more than a third of the population, including 44% of adults aged 18–59.”
And yet, the authors note this fact doesn’t appear to be a part of any policy discussion at all:
The substantial number of infections, coupled with the increasing scientific evidence that natural immunity was durable, led some medical observers to ask why natural immunity didn’t seem to be factored into decisions about prioritising vaccination.
Thursday, September 23, 2021
Dairy fat could PREVENT a heart attack
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Dairy fat from milk, butter, and cheese could actually PREVENT a heart attack SEPTEMBER 21,2021“Many studies have relied on people being able to remember and record the amounts and types of dairy foods they have eaten, which is especially difficult given dairy is commonly used in a variety of foods,” says study co-author Dr. Matti Marklund from Uppsala University, in a statement.
“Instead, we measured blood levels of certain fatty acids, or fat ‘building blocks’ that are found in dairy foods, which gives a more objective measure of dairy fat intake that doesn’t rely on memory or the quality of food databases,” Dr. Marklund continues. “We found those with the highest levels actually had the lowest risk of CVD.”
... Researchers assessed dairy fat consumption in the group of Swedish 60-year-olds by measuring blood levels of a particular fatty acid. This substance generally appears in dairy foods and is therefore useful in reflecting intake of dairy fat. Study authors tracked the group for an average of 16 years to see how many had heart attacks, strokes, and other serious circulatory events. They also looked at how many died from any cause during this time.
The CVD risk was lowest for those with high levels of the fatty acid, coming from a high intake of dairy fats. The results remained the same after accounting for factors including age, income, lifestyle, dietary habits, and other illnesses. Moreover, those with the highest levels had no increased risk of death from all causes.


Sunday, August 15, 2021
Monday, July 5, 2021
Sunday, June 27, 2021
Wednesday, June 23, 2021
Ivermectin and cancer
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Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectationsAbstract Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo’s prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck and Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.Ref added 3-Sep-2021: "Ivermectin, a potential anticancer drug derived from an antiparasitic drug", by Mingyang Tanga et al., Pharmacological Research, Volume 163, January 2021, 105207
Highlights
- Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cells.
- Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance.
- Ivermectin combined with other chemotherapy drugs or targeted drugs has powerful effects on cancer.
- The structure of crosstalk centered on PAK1 kinase reveals the mechanism by which ivermectin regulates multiple signaling pathways.
- Ivermectin has been used to treat parasitic diseases in humans for many years and can quickly enter clinical trials for the treatment of tumors.
Abstract Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies. Satoshi ōmura and William C. Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways. This suggests that ivermectin may be an anticancer drug with great potential. Here, we reviewed the related mechanisms by which ivermectin inhibited the development of different cancers and promoted programmed cell death and discussed the prospects for the clinical application of ivermectin as an anticancer drug for neoplasm therapy.
Sunday, May 30, 2021
The mechanism behind rona virus damage
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- "Identification of the antithrombotic protein S as a potential target of the SARS-CoV-2 ...", Letter to Editor, Jan A. Ruzicka, Thrombosis Research 196 (2020) 257–259
- Wiki Protein S
- "Endothelial cell damage is the central part of C...-19 and a mouse model induced by injection of the S1 subunit of the spike protein", by Gerard J. Nuovo, et al., Ann Diagn Pathol. 2021 Apr; 51: 151682.
- "SARS-COV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 Overview of Pharmacokinetic Test",
- "The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier", by Tetyana P Buzhdygan, et al., Neurobiol Dis. 2020 Dec;146:105131. doi: 10.1016/j.nbd.2020.105131. Epub 2020 Oct 11.
- "Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients", by Alana F Ogata, et al., Clinical Infectious Diseases, ciab465, Published: 20 May 2021
- Talk by Dr. Byram Bridle on the "On-Point" program with Alex Pierson, 9:11, Posted on 27-May-2021
- On-Point program with Alex Pierson, Globalnews Toronto
PROS1 | |
---|---|
* | PROMOTES ANTI-THROMBOTIC STATE |
* | AIDS IN SUPPRESSION OF COAGULATION |
* | ACTIVATES TAM (RTK) DOWNREGULATING IMMUNE FUNCTION |
* | SUPPRESSES INNATE IMMUNE FUNCTION |
* | PREVENTS CYTOKINE STORM |
* | IS SYNTHESIZED IN ENDOTHELIAL CELLS ALONGSIDE ACE2 |
SARS-CoV-2 | |
---|---|
1. | BINDS TO ACE2 PRODUCED IN ENDOTHELIUM, PENETRATES INTO ENDOTHELIAL CELLS |
2. | DESTROYS ENDOTHELIUM REDUCING PRODUCTION OF PROS1 THERE |
3. | REDUCTION OF PROS1 PROMOTES BOTH CLOTTING AND CYTOKINE STORM (RUNAWY IMMUNE RESPONSE) |
Tables 1 and 2 are based on my understanding of paper [1].
... It is concluded that ACE2+ endothelial damage is a central part of SARS-CoV2 pathology and may be induced by the spike protein alone.
Quote:
We have made a big mistake by incoculating people with the toxic spike-protein"
Quote:
To the Editor - For certain diseases, patients who have been previously infected by one strain of a virus and who are later infected by another strain can suffer outcomes that are worse than those infected only once. One explanation for this phenomenon is that differences between two viral serotypes can compromise the ability of antibodies induced by the first infection to neutralize the second one; instead, the antibodies elicited by the first infection ‘bridge’ the second viral strain to immunoglobulin G (IgG) antibody constant region (Fc) receptors on immune cells, such as macrophages. Because this bridging is believed to enable viral entry into immune cells, shifting the tropism of the virus1, the outcome manifests as an antibody-dependent enhancement (ADE) of infection and a potentially more serious recurrence of disease. This phenomenon is often observed when antibody concentrations decrease as a result of waning immunity; an antibody may neutralize potently at high concentrations but cause enhancement of infection at sub-neutralizing concentrations.More reference papers:
COVID-19 May Trigger Hyperglycemia and Worsen Disease by Harming Fat Cells OCTOBER 1, 2021
"Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2", by Moritz Reiterer et al., Cell Methabolism, September 15, 2021
Wednesday, May 26, 2021
Hydroxychloroquine and cancer
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I am posting it as a place-holder to prompt a further digging.[TO BE FINISHED LATER]
Saturday, April 3, 2021
Xenon narcolepsia in Kazakhstan
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The experiments show that besides anesthetic characteristics, xenon also has organ protective effect on heart and brain. The mechanism of this influence has not been sufficiently explained yet. According to a theory, brain damage after hypoxic/ischemic insult is caused by neuron apoptosis, which is influenced by the activation of N-methyl-D-aspartate receptor. It was demonstrated that xenon blocks this receptor. Therefore, xenon seems to be used for example in neonatal asphyxia (David 2003). After experimental occlusion of coronary artery performed in xenon anesthesia, quicker recovery of heart was demonstrated in comparison with total intravenous anesthesia (Hartlage 2004).


Highly speculative musings on the cytokine storm, WWI typhus-lice plague, Spanish Flu and vacinasions
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Thursday, March 4, 2021
Low level radiation is cancer-protective
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Two papers:1) https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1349-7006.1992.tb02342.x
Cancer Mortality Survey in a Spa Area (Misasa, Japan) with a High Radon Background Masaaki Mifune Tomotaka Sobue Hiroko Arimoto Yoshiaki Komoto Sohei Kondo Hiroshi Tanooka First published: January 1992
2) https://www.birpublications.org/doi/full/10.1259/bjr.75.895.750637
BJR > Previous Issues > Volume 75, Issue 895 > Radiation increased the longevity of British radiologists Correspondence Radiation increased the longevity of British radiologists J R Cameron 2678 SW 14th Drive, Gainesville, FL 32608, USA

