The further a society drifts from the truth, the more it will hate those who speak it. ... In a time of deceit, telling the truth is a revolutionary act. George Orwell

Wednesday, March 4, 2015

Ketogenic diet slows progression of 5 neuro degenerative diseases

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SCIENCE SUPPORTS THE ANTI-AGING AND ANTI-DEGENERATIVE PROPERTIES OF KETOGENIC DIETS!

Slowing down of neuro-degenerative disease by ketogenic diet was claimed in the recent paper:
Nourishing the Aging Brain, By Morten Scheibye-Knudsen,  The Scientist, March 2015

( in pdf format )


Quotes (see here ):

ALS:
Increased basal metabolism
Caloric restriction exacerbates progression
Ketogenic diet slows progression

ALZHEIMER’S DISEASE:
Normal or lowered basal metabolism
Caloric restriction slows progression
Ketogenic diet slows progression

PARKINSON’S DISEASE:
Increased basal metabolism
Caloric restriction slows progression
Ketogenic diet slows progression

HUNTINGTON’S DISEASE:
Increased basal metabolism
Caloric restriction may slow progression
Ketogenic diet slows progression

COCKAYNE SYNDROME [accelerated aging disease]:
Increased basal metabolism
Caloric restriction exacerbates progression
Ketogenic diet slows progression

[added on 6/03/2015, from the same source]

And the low carbohydrate (or low glucose) nutrition appears to contribute to longevity by increasing the SIRT6 activity (*), according to this paper, from the same issue of The Scientist magazine:

Wrangling Retrotransposons, by Michael Van Meter, Andrei Seluanov, and Vera Gorbunova | March 1, 2015

Quote

Perhaps the best evidence for the retrotransposon’s role in aging comes from the link between the activity of a longevity gene, SIRT6, and the repression of L1 in somatic tissues. SIRT6 encodes an enzyme critical to the forestallment of aging: it maintains telomere length, promotes DNA repair, regulates metabolism, opposes tumorigenesis, and attenuates inflammation—all processes associated with the prevention of age-related decline. Mice lacking SIRT6 suffer from a severe premature aging syndrome, while mice that overexpress SIRT6 enjoy extended life spans.

...

One explanation for this failure may relate to SIRT6’s critical role in DNA repair. Several studies have indicated that SIRT6 helps catalyze repair of the damage at numerous types of DNA lesions, including single- and double-strand breaks. A characteristic feature of aging cells is an increase in the amount of DNA damage.

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While overexpression of SIRT6 may not be tractable in a therapeutic context, SIRT6 activity can be increased by caloric restriction, reducing glucose consumption, or increasing NAD+ bioavailability (**) - interventions that have already shown promise in increasing longevity in animal models. (Such interventions are also showing promise in slowing the progress of some age-related neurodegenerative disorders.

Notes:

*) Underexpression or removal of SIRT6 gene is linked to accelerated aging disease, while overexpression of SIRT6 has been shown to extend the lifespan, in mice studies, see Wiki.

**) Niacin is one of the precursors of NAD+, another one is tryptophan.

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3 comments :

Charles Grashow said...

If you do not have one of these diseases then why is being in constant ketosis a good thing?

LeenaS said...

Why would ketosis be a bad thing?

My family have had several of those, as well as dibetes 2 in senior years. Almost ketogenic animal fat based diet has helped me for more than a decade by now :)

Thanks Stan
-- LeenaS

Stan (Heretic) said...

To slow down the aging