Very important article by Chris Masterjohn. Based on the recent Chinese paper using human stem cells in-vitro. The paper demonstrated that vitamin A acts synergistically in triggering expression of neurogenin-3. Neurogenin-3 is necessary for activation of stem cells development, in that case - for replacing the damaged insulin-producing islet cells such as in diabetes type 1.
I think that study is important for several reasons:
- Adequate intake of both A and D3 is one of the critcial factors in tissue regeneration, propably not only limited to pancreatic islets but generally to all other organs,
- Supplementation of only one of the vitamins is inadequate because both act synergistically.
- I suspect (speculating) that beta carotene might not be adequate if vitamin D3 level is low, and vice versa - supplementation of D3 might not be effective in the absence of A. We shall keep in mind that beta carotene (pro-vitamin A) from plants is NOT the true vitamin A! This may explain a curious fact of difficult to treat vitamin A or vitamin D3 depletions frequently reported by vegans.
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