Since late 2016 we have entered the age of disclosures! Fasten your mental safety belt and enjoy the ride! Heretic

Friday, September 21, 2018

No benefit in LDL-C lowering, trend toward harm.

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No beneficial relationship was found between LDL-C lowering and cardiovascular events explored by meta-regression; instead, there was a trend toward harm.

The systematic review ...,Battaggia A, et al. Curr Med Res Opin. 2018.

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CONCLUSIONS: The relationship between LDL-C lowering and cardiovascular events has not showed any significant association (and even a tendency toward harm), challenging the "lower the better" theory. A separate meta-analysis of trials recruiting familial hypercholesterolemia patients has showed a tendency to harm for all outcomes with PCSK9 antibodies. Therefore, at the moment, the data available from randomized trials does not clearly support the use of these antibodies.

2 comments :

Bob said...

What a shame. What a surprise.

Stan Bleszynski said...

Its a good news for people - no need to take $tatins!