Since late 2016 we have entered the age of disclosures! Fasten your mental safety belt and enjoy the ride! Heretic

Wednesday, December 19, 2018

We don't need no plants antioxidants!

- probably! As hinted in the following study:

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases", by
Daniele Del Rio, et al., Antioxid Redox Signal. 2013 May 10; 18(14): 1818–1892.

Very poor absorption of plants' poly-phenolic anti-oxidants! From milli-Mole in food down to nano-Mole concentration in the body! Quickly destroyed and eliminated by the body! After decades of hypothesizing and speculations - no direct evidence of health benefits!


...exist in planta, at concentrations in the low-μM-to-mM range. However, after ingestion, dietary (poly)phenolics appear in the circulatory system not as the parent compounds, but as phase II metabolites, and their presence in plasma after dietary intake rarely exceeds nM concentrations. Substantial quantities of both the parent compounds and their metabolites pass to the colon where they are degraded by the action of the local microbiota,
Evidence relating to the anticancer effects of (poly)phenols is limited. The majority of available clinical evidence has been with green tea/(poly)phenols in populations at a high risk of cancer development, with results proving inconclusive.
While a few of studies suggest that (poly)phenol-rich foods prevent lymphocyte DNA damage, no direct link with a decrease in cancer risk can be established from those studies.
As yet, it is too premature to consider the potential use of (poly)phenolic compounds as therapeutic agents.

Updated 22/12/2018

This is probably the main reason why dietary anti-oxidants don't work:

"Antioxidants prevent health-promoting effects of physical exercise in humans"
by Michael Ristow, et. al., PNAS May 26, 2009 106 (21) 8665-8670; March 31, 2009

...We evaluated the effects of a combination of vitamin C (1000 mg/day) and vitamin E (400 IU/day) on insulin sensitivity as measured by glucose infusion rates (GIR) during a hyperinsulinemic, euglycemic clamp in previously untrained (n = 19) and pretrained (n = 20) healthy young men. Before and after a 4 week intervention of physical exercise, GIR was determined, and muscle biopsies for gene expression analyses as well as plasma samples were obtained to compare changes over baseline and potential influences of vitamins on exercise effects. Exercise increased parameters of insulin sensitivity (GIR and plasma adiponectin) only in the absence of antioxidants...
Consistent with the concept of mitohormesis, exercise-induced oxidative stress ameliorates insulin resistance and causes an adaptive response promoting endogenous antioxidant defense capacity. Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.


john said...

The oversimplified mainstream view on antioxidants is that they're little "anti-aging packets." Another strange attitude is that animals foods are protein plus fat, while plants have all the vitamins, minerals, and fiber--the "important" stuff.

I eat peppers and some other vegetables and herbs to flavor dishes, but people are usually shocked when they ask me about my diet. You spend time in the pro-saturated fat corners of the internet, and you forget how unpopular it still is out in the world.

Stan Bleszynski said...

Hi John,
Animal produce has more than just fat and protein, especially organ meat, bone marrow, egg yolks etc. Carnivorous diets are still not that common but are not as unpopular as they used to be, especially after Jordan Peterson & David Rubin interview in January this year. Peterson has got millions of followers so it had a huge impact. Some people have no choice (no sane choice I mean) and are being pushed into keto diets kicking and screaming when they realize the alternatives are worse. Regarding plants, I used to think so too, but the more research hits the fan the more I realize that plant vitamins and their anti-oxidants are either useless (for us) or harmful.

Regards, Stan

Larcana said...

I have argued with the folks that are in to pulverizing plants in a blender...the chemicals in plants are numerous and not all are friendly. I'm not surprised that the available "nutrients" are not all that available.

Peter said...

Hi Stan and all, I think it's more a matter of actively getting rid of plant antioxidants. If anything is going to mangle your ROS signalling system as badly as antioxidants might do then the priority must be to get rid of them asap. That's why we have a liver, amongst other reasons!

Seasons greetings


Stan Bleszynski said...

Hi Peter,

It also explains various problems that vegetarians experience even if they reduce carbohydrates. In a weird sense, some veg promoters like McDougall advising them eat more starch are doing probably less harm than a classical vegan/Natural Hygiene style diet based on green vegetables and beans.

Happy Winter Solstice and Kolęda Kolęda(*)!
Best regards,

( * = Slavic Pagan God of New Dawn)

Stan Bleszynski said...


A friend once sent me a tip about it: - blended vegetables are less sticky and much easier to slide right out into a composting bin. :)
Best regards,

Anonymous said...

Would the results of this study come out the same, if controlling for other factors were included? Factors, such as, food sources, P:F:C amounts, organic, grass-fed, etc. And why not do a study on the very ill or elderly or very obese, or bedridden?

It is possible that important information on other factors would become known.