The further a society drifts from the truth, the more it will hate those who speak it. ... In a time of deceit, telling the truth is a revolutionary act. George Orwell

Saturday, August 11, 2012

Glucose and epileptic seizures

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Interesting paper, requires more discussion (to be added later):


Fructose-1,6-Bisphosphate Has Anticonvulsant Activity in Models of Acute Seizures in Adult Rats


A variety of observations suggest that decreasing glycolysis and increasing levels of reduced glutathione, generated by metabolism of glucose through the pentose phosphate pathway, would have an anticonvulsant effect. 

Glucose is the primary source of energy for the CNS. Imaging of children with Lennox–Gastaut and infantile spasms has shown decreased glucose utilization between seizures and excessive glycolysis immediately before, and during, seizures (Chugani and Chugani, 1999). 

Evidence suggests that the changes in glucose metabolism and decreased glutathione levels observed in the brains of patients with epilepsy favor the generation of each seizure. First, hyperglycemia has been associated with seizure activity (Schwechter et al., 2003Lammouchi et al., 2004), whereas relative hypoglycemia has been shown to have an anticonvulsant effect (Greene et al., 2001). Second, the ketogenic diet (KD), which provides energy substrates for the brain that bypass glycolysis, has been shown to be an effective treatment for seizures (Freeman et al., 2007). Finally, animals with low levels of GSH have a low seizure threshold or spontaneous seizures (Wu et al., 2004).

[add discussion]

1 comment :

Leslie Joy said...

I am a 59 yr woman. I have used every medication but could not find one that would have seizures completely under control. Lamictol helps but only partially. I had to find something to keep them totally undercontrol. Constant prayer, CBD, High-protein/fat worked only partially. The trick was using all plus a Glucose and Sugar Free. I also am hypothyroid to boot. I take meds for that as well. So vitamin and mineral supplements were a need be. Personally speaking there was no one way. Sleep, and emotional/mental stress levels have also been factors. Epilepsy is a mystery. I believe doctors give themselves too much praise. It has been mine, and many others, experience that they are very limited in answers. The answers are out there but the patient has to do most of the investigation themselves.