Hold off those berries and vitamins, suggests DNA discoverer James Watson, in today's article titled "DNA pioneer James Watson takes aim at 'cancer establishments'" article.
On the $100 million U.S. project to determine the DNA changes that drive nine forms of cancer: It is "not likely to produce the truly breakthrough drugs that we now so desperately need," Watson argued. On the idea that antioxidants such as those in colorful berries fight cancer: "The time has come to seriously ask whether antioxidant use much more likely causes than prevents cancer."
That is why Watson advocates a different approach: targeting features that all cancer cells, especially those in metastatic cancers, have in common.
One such commonality is oxygen radicals. Those forms of oxygen rip apart other components of cells, such as DNA. That is why antioxidants, which have become near-ubiquitous additives in grocery foods from snack bars to soda, are thought to be healthful: they mop up damaging oxygen radicals.
That simple picture becomes more complicated, however, once cancer is present. Radiation therapy and many chemotherapies kill cancer cells by generating oxygen radicals, which trigger cell suicide. If a cancer patient is binging on berries and other antioxidants, it can actually keep therapies from working, Watson proposed.
"Everyone thought antioxidants were great," he said. "But I'm saying they can prevent us from killing cancer cells."