Since late 2016 we have entered the age of disclosures! Fasten your mental safety belt and enjoy the ride! Heretic

Thursday, December 1, 2011

Arterial plaque = glucose + insulin, C14 traced study

Atheroma (from wiki)

A "blast from the past": two old forgotten papers that were never followed up, as far as I was able to find.  I wonder why not?

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INSULIN STIMULATED LIPOGENESIS IN ARTERIAL TISSUE IN RELATION TO DIABETES AND ATHEROMA
R. W. Stout, Lancet p702,1968

Summary

Discussion (p1 of 2)
Discussion (p2 of 2)


INSULIN STIMULATION OF CHOLESTEROL SYNTHESIS BY ARTERIAL TISSUE

R.W. Stout, Lancet p467,1969


Summary
Discussion (p1 of 2)
Discussion (p2 of 2)

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Dav0 found a more recent paper by Stout (thanks):


Insulin and Atheroma: 20-Yr Perspective, Robert W Stout, MD, DSc, FRCP

Quote:

Five population studies have shown that insulin responses to glucose are higher in populations at greater risk of cardiovascular disease. Many of the hyperinsulinemic populations also had upper-body obesity, hypertriglyceridemia, lower highdensity lipoprotein (HDL) levels, and hypertension. These prospective studies support an independent association between hyperinsulinemia and ischemic heart disease, although their results differ in detail. Hyperinsulinemia is associated with raised triglyceride and decreased HDL cholesterol levels.






.

4 comments :

john said...

Good stuff--I remember Emma of Plant Poisons once mentioned the experiment with dogs and the femoral artery, but I never searched it out. I would like to see some of these measurements in experiments comparing a real food fat based diet vs starch.

As far as I know there is nothing too thorough, but there is a study comparing a "meat and milk based" diet, a cereal/grain pellet based diet, and another high fat (higher in PUFA) diet, which does look at some aging indicators like lipofuscin and tail tendon breaking time. The meat and milk diet came out looking best.

Scott said...

Good question. Maybe you could contact Prof. Stout?

Stan (Heretic) said...

I did email him years ago (probably 10), no answer. Also, Stout never published anything on this particular subject ever again. You can check it on pubmed. He is is or was a university dean, president of the Ulster Medical Society etc etc, probably too busy. On the other hand he did publish other papers. I guess the subject mustn't have been important enough. Hmmm...
A bit puzzling, isn't it?

Heretic

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P.S.

See this.

Robert W Stout, MD, DSc, FRCP, FMedSc, Professor of Geriatric Medicine.

Correspondence to Professor R W Stout, Department of Geriatric Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL. Tel: 028 9033 5777. Fax: 028 9032 5839.

email: r.stout@qub.ac.uk

dav0 said...

Stan, Here's a link to a 20 year retrospective on the original article together with a list of refs that cite this:

http://care.diabetesjournals.org/content/13/6/631.short