Telomere length correlates with red meat consumption

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Blog article:

Unexpected relationship between Red Meat Diet and PBMC Telomere Length, Sep 28, 2016 1:30:54 AM / by Stacy Matthews Branch, DVM, PhD

Update 15-Jan-2020

500% extension for C.Elegans by TOR and Insulin IIS signaling modification:
Pathways that extend lifespan by 500 percent identified Discovery of cellular mechanisms could open door to more effective anti-aging therapies, Date:January 8, 2020, Mount Desert Island Biological Laboratory

Quote:

The new research uses a double mutant in which the insulin signaling (IIS) and TOR pathways have been genetically altered. Because alteration of the IIS pathways yields a 100 percent increase in lifespan and alteration of the TOR pathway yields a 30 percent increase, the double mutant would be expected to live 130 percent longer. But instead, its lifespan was amplified by 500 percent.

Reference:

"The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat.", Kasielski M, Eusebio MO, Pietruczuk M, Nowak D., Nutr J. 2016 Jul 14;15(1)

Fig.1 from the paper above.

Mount Desert Island Biological Laboratory. "Pathways that extend lifespan by 500 percent identified: Discovery of cellular mechanisms could open door to more effective anti-aging therapies." ScienceDaily. ScienceDaily, 8 January 2020.

Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di Chen. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019; 28 (4): 1050 DOI: 10.1016/j.celrep.2019.06.078

Mediterranean diet is good, adding meat & dairy makes it better!

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as the following two studies have recently demonstrated:

1) "A Mediterranean-style eating pattern with lean, unprocessed red meat has cardiometabolic benefits for adults who are overweight or obese in a randomized, crossover, controlled feeding trial",
Lauren E O'Connor, Douglas Paddon-Jones, Amy J Wright, Wayne W Campbell,
The American Journal of Clinical Nutrition, Volume 108, Issue 1, 1 July 2018, Pages 33–40

Note: they used lean read meat. I predict a follow-up study titled "A Mediterranean-style eating pattern with fatty, unprocessed red meat has the greatest cardiometabolic benefits"!


2) "A Mediterranean diet supplemented with dairy foods improves markers of cardiovascular risk: results from the MedDairy randomized controlled trial",
Alexandra T Wade, Courtney R Davis, Kathryn A Dyer, Jonathan M Hodgson, Richard J Woodman, Karen J Murphy,
The American Journal of Clinical Nutrition, nqy207, https://doi.org/10.1093/ajcn/nqy207
Published: 22 October 2018


Quote:

Results
Compared with the LF intervention, the MedDairy intervention resulted in a significantly lower morning SBP (mean difference: −1.6 mm Hg; 95% CI: −2.8, −0.4 mm Hg; P = 0.01), lower morning diastolic blood pressure (mean difference: −1.0; 95% CI: −1.7, −0.2 mm Hg; P = 0.01) and clinic SBP (mean difference: −3.5 mm Hg; 95% CI: −6.4, −0.7 mm Hg; P = 0.02), significantly higher HDL cholesterol (mean difference: 0.04 mmol/L; 95% CI: 0.01, 0.06 mmol/L; P < 0.01), lower triglycerides (mean difference: = −0.05 mmol/L; 95% CI: −0.08, −0.01 mmol/L; P < 0.01), and lower ratio of total to HDL cholesterol (mean difference: −0.4; 95% CI: −0.6, −0.2; P < 0.001). No effects were observed for other outcome measures. Conclusions
Following a MedDiet with additional dairy foods led to significant changes in markers of cardiovascular risk over 8 wk. The MedDiet supplemented with dairy may be appropriate for an improvement in cardiovascular risk factors in a population at risk of CVD.