Low-salt diet increases insulin resistance in healthy subjects

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Interesting study:


Low-salt diet increases insulin resistance in healthy subjects.
Garg R1, Williams GH, Hurwitz S, Brown NJ, Hopkins PN, Adler GK., Metabolism. 2011 Jul;60(7)

From Wiki Salt

Quote:

Abstract
Low-salt (LS) diet activates the renin-angiotensin-aldosterone and sympathetic nervous systems, both of which can increase insulin resistance (IR). We investigated the hypothesis that LS diet is associated with an increase in IR in healthy subjects. Healthy individuals were studied after 7 days of LS diet (urine sodium < 20 mmol/d) and 7 days of high-salt (HS) diet (urine sodium > 150 mmol/d) in a random order. Insulin resistance was measured after each diet and compared statistically, unadjusted and adjusted for important covariates. One hundred fifty-two healthy men and women, aged 39.1 ± 12.5 years (range, 18-65) and with body mass index of 25.3 ± 4.0 kg/m(2), were included in this study. Mean (SD) homeostasis model assessment index was significantly higher on LS compared with HS diet (2.8 ± 1.6 vs 2.4 ± 1.7, P < .01). Serum aldosterone (21.0 ± 14.3 vs 3.4 ± 1.5 ng/dL, P <  .001), 24-hour urine aldosterone (63.0 ± 34.0 vs 9.5 ± 6.5 μg/d, P < .001), and 24-hour urine norepinephrine excretion (78.0 ± 36.7 vs 67.9 ± 39.8 μg/d, P < .05) were higher on LS diet compared with HS diet. Low-salt diet was significantly associated with higher homeostasis model assessment index independent of age, sex, blood pressure, body mass index, serum sodium and potassium, serum angiotensin II, plasma renin activity, serum and urine aldosterone, and urine epinephrine and norepinephrine. Low-salt diet is associated with an increase in IR [insulin resistance]. The impact of our findings on the pathogenesis of diabetes and cardiovascular disease needs further investigation.

Study contradicts official guidelines promoting low salt intake

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Another mainstream medical theory bites the dust! Just like with the cholesterol-and-fat bull..t in the past - it will be interesting to find out what has gone wrong and who did it!   :)

Higher sodium intake associated with lower blood pressure.

PUBLIC RELEASE: 25-APR-2017
Low-sodium diet might not lower blood pressure
Findings from large, 16-year study contradict sodium limits in Dietary Guidelines for Americans

Quotes:

Chicago (April 25, 2017) - A new study that followed more than 2,600 men and women for 16 years found that consuming less sodium wasn't associated with lower blood pressure. The new findings call into question the sodium limits recommended by the current Dietary Guidelines for Americans.

Lynn L. Moore, DSc, associate professor of medicine at Boston University School of Medicine, will present the new research at the American Society for Nutrition Scientific Sessions and annual meeting during the Experimental Biology 2017 meeting, to be held April 22-26 in Chicago.

"We saw no evidence that a diet lower in sodium had any long-term beneficial effects on blood pressure," said Moore. "Our findings add to growing evidence that current recommendations for sodium intake may be misguided."