"IGF-I activity may be a key determinant of stroke risk--a cautionary lesson for vegans.", McCarty MF.
(Quoting here the first half of the abstract describing facts leaving out the second part containing some wishful thinking.)
Abstract
IGF-I acts on vascular endothelium to activate nitric oxide synthase, thereby promoting vascular health; there is reason to believe that this protection is especially crucial to the cerebral vasculature, helping to ward off thrombotic strokes. IGF-I may also promote the structural integrity of cerebral arteries, thereby offering protection from hemorrhagic stroke. These considerations may help to explain why tallness is associated with low stroke risk, whereas growth hormone deficiency increases stroke risk - and why age-adjusted stroke mortality has been exceptionally high in rural Asians eating quasi-vegan diets, but has been declining steadily in Asia as diets have become progressively higher in animal products. There is good reason to suspect that low-fat vegan diets tend to down-regulate systemic IGF-I activity; this effect would be expected to increase stroke risk in vegans. Furthermore, epidemiology suggests that low serum cholesterol, and possibly also a low dietary intake of saturated fat - both characteristic of those adopting low-fat vegan diets - may also increase stroke risk. ...
6 comments :
Low IGF factors is generally not a problem if the salt/sodium intake is low and blood pressure is kept low.
Also low IGF is linked to lower rates of cancer.
http://exchanges.webmd.com/diet-debate
Yes, there seems to be some link with IGF-1 and cancer although I am not 100% sure if that is real. For example, if the growth hormones were the major factor then how come that the cancer risk increases dramatically with age at the same time as the growth hormones decline also dramatically with age?
Thus, diets featuring vegan proteins can be expected to lower elevated serum lipid levels, promote weight loss, and decrease circulating IGF-I activity. The latter effect should impede cancer induction (as is seen in animal studies with soy protein), lessen neutrophil-mediated inflammatory damage, and slow growth and maturation in children. In fact, vegans tend to have low serum lipids, lean physiques, shorter stature, later puberty, and decreased risk for certain prominent 'Western' cancers; a vegan diet has documented clinical efficacy in rheumatoid arthritis. Low-fat vegan diets may be especially protective in regard to cancers linked to insulin resistance--namely, breast and colon cancer--as well as prostate cancer; conversely, the high IGF-I activity associated with heavy ingestion of animal products may be largely responsible for the epidemic of 'Western' "
Probably because getting older is the greatest risk fator of all.
IGF-I acts on vascular endothelium to activate nitric oxide synthase, thereby promoting vascular health; there is reason to believe that this protection is especially crucial to the cerebral vasculature, helping to ward off thrombotic strokes.
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